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Apathy, depression, and dementia risk in older adults: A global collaborative study
- Oh, Dae Jong;
- Lipnicki, Darren M.;
- Harrison, Fleur;
- Han, Ji Won;
- Kim, Tae Hui;
- ... Lee, Seok Bum;
- ... Lee, Jung Jae;
- 외 32명
WEB OF SCIENCE
1SCOPUS
5초록
INTRODUCTION: The role of apathy in predicting dementia risk, especially with coexisting depression, remains unclear in community-dwelling older adults. METHODS: We analyzed data from 12,646 older adults without baseline dementia across ten population-based cohorts from six continents (Cohort Studies of Memory in an International Consortium study). Apathy, depression, and dementia outcomes were assessed using harmonization protocols. RESULTS: Over 5.7 years of follow-up, 1160 developed dementia and 552 Alzheimer's disease (AD). Apathy prevalence was 34.1% and more than three times higher in those with depression. Apathy was not associated with dementia risk among cognitively normal or non-depressed individuals. In contrast, among individuals with depression and mild cognitive impairment (MCI), apathy predicted a higher risk of dementia (hazard ratio [HR] 1.62) and AD (HR 1.74). DISCUSSION: Apathy is associated with increased dementia risk only in older adults withMCIand depression. Findings highlight the need to incorporate affective symptom monitoring into dementia risk assessment and intervention.
키워드
- 제목
- Apathy, depression, and dementia risk in older adults: A global collaborative study
- 저자
- Oh, Dae Jong; Lipnicki, Darren M.; Harrison, Fleur; Han, Ji Won; Kim, Tae Hui; Kwak, Kyung Phil; Kim, Bong Jo; Kim, Shin Gyeom; Kim, Jeong Lan; Moon, Seok Woo; Park, Joon Hyuk; Ryu, Seung-Ho; Youn, Jong Chul; Lee, Dong Young; Lee, Dong Woo; Lee, Seok Bum; Lee, Jung Jae; Jhoo, Jin Hyeong; Castro-Costa, Erico; Davis, Daniel; Lipton, Richard B.; Katz, Mindy J.; Preux, Pierre-Marie; Guerchet, Maelenn; Scarmeas, Nikolaos; Yannakoulia, Mary; Kosmidis, Mary; Rolandi, Elena; Davin, Annalisa; Rossi, Michele; Gureje, Oye; Ojagbemi, Akin; Elugbadebo, Olufisayo; Riedel-Heller, Steffi; Roehr, Susanne; Pabst, Alexander; Brodaty, Henry; Sachdev, Perminder S.; Kim, Ki Woong
- 발행일
- 2025-12
- 유형
- Article
- 권
- 21
- 호
- 12
- 언어
- ENG
- 출판사
- Wiley
- 발행국가
- 미국
- ISSN
- E 1552-5279
P 1552-5260